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AOD-9604: measurable fat loss within 3-4 weeks, visible changes by weeks 6-8 CJC-1295 + Ipamorelin: noticeable body composition changes at 4-6 weeks Semaglutide: rapid appetite suppression within days, significant weight loss over months (1-2 lbs/week, peak at 60-68 weeks) MOTS-c: subtle improvements over 6-8 weeks Focus on 8-12 week evaluation periods