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As a result of oxidative stress, the reactive intermediates produced can react with the polyunsaturated fatty acids of lipid membranes and cause lipid peroxidation [24]

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NAC for the Treatment of Depression Chronic pain and depression often coexist, and activation of specific brain regions that are associated with the so- called “pain matrix,” including the insula, cingulate cortex, and amygdala, play a key role in the regulation of mood and in the mechanisms of resilience to stress