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In summary, niacin is essential to the biochemistry of the nervous system, contributing to energy metabolism, neurotransmitter synthesis, such as serotonin and dopamine, antioxidant activities, and DNA repair (3, 11, 13, 56)

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By dosage, the mean changes were: 500 mcg: ∼127% 750 mcg: ∼176% (single study) 1,000 mcg: ∼280% 1,500 mcg: ∼310% 2000 mcg: ∼260% 5,000 mcg: ∼62% While 1,500 mcg of vitamin B12 showed the highest average increase, the effect plateaued or declined at higher doses, suggesting a possible saturation of absorption pathways