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In the early endosomes, internalized GPCRs undergo dephosphorylation by protein phosphatase 2A (PP2A) to be recycled back to the plasma membrane, where they become ready to be activated and respond to a new wave of stimuli (Gupta et al., 2018

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early studies showed that ITCs block new blood vessel formation and epithelial–mesenchymal transition (EMT) in tumors (122)