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GSH deficiency as evidenced by a decrease in the GSH/GSSG ratio manifests itself largely through an increased susceptibility to oxidative stress, and the resulting damage is thought to be involved in SARS-CoV-2 infection leading to COVID-19 disease (6, 7, 39, 43–53)
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Additionally, this pathway can inhibit activated protein kinase C and reduce coenzyme II (nicotinamide adenine dinucleotide phosphate, NADPH) activity, alleviate ER stress and lipid accumulation (Jin et al., 2021), scavenge accumulated oxidative products, and reverse oxidative stress damage in nerve cells, thereby delaying or preventing the progression of VaD