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Phase (approx.) Cagrilintide dose Frequency Weeks 1–4 0.25 mg Once weekly Weeks 5–8 0.5 mg Once weekly Weeks 9–12 1.0 mg Once weekly Weeks 13–16 1.7 mg Once weekly Week 17 onward 2.4 mg (max studied) Once weekly This step-wise schedule mirrors the titration used in cagrilintide and CagriSema studies ( Lau et al., Lancet 2021