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Additionally, oxidative stress is closely related to defects in keratinocytes, melanocytes, and the extracellular microenvironment

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While BPC 157 provided a consistent beneficial effect (10 μg/kg bath (1 mL/rat) increased vessel presentation with inside/outside arcade interconnections’ quick reappearing, mucosal folds’ preservation, and the pale areas becoming small and markedly reduced), NO-agents have a more complex effect