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A 12-week randomized, double-blind, placebo-controlled, parallel-group trial by Dollerup, Christensen, and colleagues published in the American Journal of Clinical Nutrition in 2018 tested nicotinamide riboside supplementation at 1,000 mg twice daily (2,000 mg/day total) in 40 obese, insulin-resistant men and concluded that while the dose appeared safe, NR did not improve insulin sensitivity, endogenous glucose production, or whole-body glucose disposal or oxidation compared with placebo